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Research

Research Strength

Bioactive Compounds (BC)

Research Strength - Bioactive Compounds (BC)

Vision
The vision of the Bioactive Compounds Research Strength at Monash University Sunway Campus is to become an excellent research and educational resource for Bioactive Compound research. It will provide a framework to foster interdisciplinary interaction and integration of resources to improve and promote a collaborative culture that stimulates research projects in Bioactive Compounds, leading to the development of highly productive interdisciplinary research teams.

Introduction

Bioactive compounds are molecules having biochemical effects in man, animals and microbes. There are huge amount of such compounds, which have a broad range of effects, ranging from being acute deadly to being healthy or curative. These compounds can be naturally found in plants and living organisms, chemically modified or synthetically made. Bioactive compounds have been continuously being isolated and characterized from numerous sources and they form the basis of modern pharmacology and medical treatment, and as natural beneficial compounds in food and supplements. Besides being beneficial, there are also a large number of bioactive compounds that behave as acute poisons and contaminants in food and in the environment that we lived in. These compounds are toxic, implying potential risks of adverse effects to man and animals.

The objectives of this research strength are:

To promote interdisciplinary collaboration among research groups.
To encourage basic and applied research in Bioactive Compounds and maximize research output and productivity leading to intellectual property rights and commercialization.
To seek new research partnerships with public, private and international researchers and strengthen existing partnerships.
To increase research funding utilizing collective strengths to submit competitive research proposals.
To provide new educational experience by organizing symposium, workshop and seminars.
To increase HDR studentships and funding for instrumentation and research assistantships.
To increase publication and dissemination of research findings and active participation in national and international meetings.

Schools

School of Science (Sunway Campus)
School of Medicine & Health Sciences (Sunway Campus)

Collaborations and partnerships

CARIFF
International Medical University
Institute of Medical Research (Malaysia)
University of Technology Mara
University Kebangsaan Malaysia
University Putra Malaysia
University of Leicester, UK
University of Nottingham, UK

Research Strength Leader : A/Prof. Chow Sek Chuen

Staff Members

School of Science	School of Medicine and Health Sciences
Prof. Benjamin Li Prof. Gary Dykes A/Prof. Song Keang Peng A/Prof. Chow Sek Chuen A/Prof. Lim Yau Yan Dr. Anne Vaughan Dr. Choo Wee Sim Dr. Goh Joo Kheng Dr. Juan Joon Ching Dr. Kumaran Narayanan Dr. Siow Lee Fong Dr. Tam Sheh May Dr. Adeline Ting Su Yien Dr. Lee Sui Mae Dr. Ton So Ha Ms. Pushpamalar A/P Janarthanan Dr. Song Beng Kah	Prof. Iekhsan Othman A/Prof. Wong Chee Piau Dr. Jaya Vejayan Dr. Tang Kim San Dr. Wong Yoon Sim Dr. Ong Chin Eng Dr. Thet Thet Htar Dr. Uma Palanisamy Dr. Saravanan Muniyandy Dr. Ng Khuen Yen

Research strength affiliate members

Prof. Cheng Hwee Ming
Prof. Fredrick Weber
Prof. Ammu K.C. Krishnan
Prof. Mak Joon Wah
Dr. Gan Seng Chiew

Publications

2009 Publications

Choo WS, Birch EJ, Stewart, I (2009) Radical scavenging activity of lipophilized products from transesterification of flaxseed oil with cinnamic acid or ferulic acid. Lipids 44: 807-815. (IF: 1.888)

Choo WS (2009) Cold-Pressed Flaxseed Oils: Characterization of Cold-Pressed Flaxseed Oils and Products from their Enzymatic Transesterification with Cinnamic and Ferulic acids. VDM Verlag Dr Muller 1-157.

Lim YAL, Romano N, Colin N, Chow SC, Smith HV (2009) Intestinal parasitic infections amongst Orang Asli (indigenous) in Malaysia: Has socioeconomic development alleviated the problem?. Tropical Biomedicine 26 (2): 110-122. (IF: 0.590)

Wong LF, Lim YY, Omar M (2009) Antioxidant and antimicrobial activities of some Alpina species. Journal of Food Biochemistry 33: 835-851. (IF: 0.80)

Ghosh AK, Chauhan N, Rajakumari S, Daum G, Rajasekharan R (2009) At4g24160, a soluble acyl-coenzyme A-dependent lysophosphatidic acid acyltransferase. Plant Physiology 151: 869-881. (IF: 6.11)

Tam SM, Samipak S, Britt A, Chetelat RT (2009) Characterization and comparative sequence analysis of the DNA mismatch repair MSH2 and MSH7 genes from tomato. Genetica 137: 341-354. (IF: 1.98)

Lim WYA, Chia YY, Liong SY, Ton SH, Khalid AK, Sharifah NASH (2009) Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats. Lipids in Health and Disease 8(31): 1-10. (IF: 2.062)

Chow SC (2009) Immunomodulation by statins: mechanisms and potential impact on autoimmune diseases. Arch. Immunol. Ther. Exp.57: 1-9 (IF: 1.43)

Lim TY, Lim YY, Yule C (2009) Evaluation of antioxidant, antimicrobial and anti-tyrosinase activities of four Macaranga species. Food Chemistry 114: 594-599. (IF: 2.70)

Chan EWC, Lim YY, Wong SK, Lim KK, Lianto FS, Yong MY (2009) Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species. Food chemistry 113: 166-172. (IF: 2.70)

Chan EWC, Lim YY, Ling SK, Tan SP, Lim KK, Khoo MGH (2009) Caffeoylquinic acids from leaves of Etlingera species (Zingiberaceae). LWT 42: 1026-1030. (IF: 1.89)

Chew YL, Goh JK, Lim YY (2009) Assessment of in vitro antioxidant capacity and polyphenolic composition of selected medicinal herbs from Leguminosae family in Peninsular Malaysia. Food Chemistry 116: 13-18. (IF: 2.70)

Lai HY, Lim YY, Tan SP (2009) Antioxidant, tyrosinase inhibition and antibacterial activities of the leaf extracts from medicinal ferns. Bioscience, Biotechnology, and Biochemistry. (In press). (IF: 1.39)

Wong SK, Lim YY, Chan EWC (2009) Antioxidant properties of Hibiscus: Species variation, altitudinal change, coastal influence, and floral colour change. Journal of Tropical Forest Science. (In press) (IF: 0.48)

Narayanan, K., Sim, E.U, Ravin, N.V., and Lee, C.W. (2009). Recombination between double-stranded DNA substrates in vivo. Analytical Biochemistry 387: 139-141. (IF: 3.002)

Lee, C.W., Ng, A.Y., Narayanan, K., Sim, E.U., Ng, C.C. (2009). Isolation and characterization of culturable bacteria from tropical coastal waters. Ciencias Marinas 35: 153-167. (IF: 0.82)

Lai Teng Ling, Su-Ann Yap, Ammu K. Radhakrishnan, Hwee, Ming Cheng and Uma D. Palanisamy (2009). Standardised Mangifera indica extract an ideal antioxidant, Food Chem. 113, 1154–1159 (IF: 2.70)

2008 Publications

W. T. Tan, J.K. Goh (2008) Electrochemical Oxidation of Methionine Mediated by a Fullerene-C₆₀ Modified Gold Electrode. Electroanalysis 20(22):2447-2453. (IF: 2.95)

Juan JC, Zhang, JC, Yarmo, MA (2008) Study of catalyst comprising zirconium sulfate supported on a mesoporous molecular sieve HMS for esterification of fatty acid under solvent-free condition. Appl Catalysis A: General 347: 133-141. (IF: 3.17)

Lau YL, Fong MY (2008) Toxoplasma gondii: Serological characterization and immunogenicity of recombinant surface antigen 2 (SAG2) expressed in the yeast Pichia pastoris. Experimental Parasitology 119: 373 – 378. (IF: 1.59)

Chan EWC, Lim YY, Wong LF, Lianto FS, Wong SK, Lim KK, Joe CE, Lim TY (2008) Antioxidant and tyrosinase inhibition properties of leaves and rhizomes of ginger species. Food Chemistry 109: 477– 483. (IF: 3.05)

Chew YL, Lim YY, Omar M, Khoo KS (2008) Antioxidant activity of edible seaweeds from two areas in South East Asia. LWT - Food Science and Technology 41: 1067–1072. (IF: 1.59)

Juan JC, Zhang JC & Yarmo MA (2008) Efficient esterification of fatty acids with alcohols catalyzed by novel green Zr(SO4)2.4H2O catalyst under solvent free conditions. Catalysis Lett 2008: 319-324. (IF: 1.88)

Sharaniza,Ab-Rahim, L.Selvaratnam, I.Othman and T.Kamarul (2008) The Role of TGF-B1 on chondrocyte focal adhesion and regulation of extracellular matrix synthesis, The FEBS Journal (2008), 275 (Supp1) ,439. (IF: 3.26)

Narayanan, K. (2008). Intact recombineering of highly repetitive DNA requires reduced induction of recombination enzymes and improved host viability. Analytical Biochemistry 375: 394-396. (IF: 3.00)

Ooi, Y.S., Warburton, P.E., Ravin, N.V., and Narayanan, K. (2008). Recombineering linear DNA that replicate stably in E. coli. Plasmid 59: 63-71. (IF: 2.041)

Singh R, Ting JG, Pan Y, Teh LK, Ismail R and Ong CE (2008). Functional role of Ile264 in CYP2C8: mutations affect haem incorporation and catalytic activity. Drug Metabolism and Pharmacokinetics 23: 165-174. (IF:2.64)

Ghosh AK, Ramakrishnan G, Chandramohan C, Rajasekharan R (2008) CGI-58, the causative gene for Chanarin-Dorfman Syndrome, mediates acylation of lysophosphatidic acid. Journal of Biological Chemistry 283: 24525–24533. (IF: 5.58)

Ghosh AK, Ramakrishnan G, Rajasekharan R (2008) YLR099C (ICT1) Encodes for a soluble acyl-CoA-dependent lysophosphatidic acid acyltransferase responsible for enhanced phospholipid synthesis upon organic solvent stress in Saccharomyces cerevisiae. Journal of Biological Chemistry 283:9768–9775. (IF: 5.58)

Uma D. Palanisamy, Cheng, H.M., Theanmalar, M., Thavamanithevi, S., Ling, L.T., Yap, S.A., and Radhakrishnan, A.K. (2008). Nephelium lappaceum skin peel extracts with high free radical scavenging activity for cosmeceutical and nutraceutical applications., Food Chem. 109(1), 54-63. (IF: 2.70)

2007 Publications

J.Vejayan, H.Ibrahim and I.Othman (2007) The potential of Mimosa pudica (Mimosaceae) against snake envenomation, Journal of Tropical Forest Science 19,(4), 189- 197 (IF: 0.48)

Fong MY, Lau YL, Zulqarnain M (2007) Characterization of secreted recombinant Toxoplasma gondii surface antigen 2 (SAG2) heterologously expressed by the yeast Pichia pastoris. Biotechnol Lett 30: 611 – 618 (IF: 1.13)

Chan E WC, Lim YY, Chew Y L (2007) Antioxidant activity of Camellia sinensis leaves and tea from a lowland plantation in Malaysia. Food Chem 102: 1214-1222 (IF: 2.43)

Lim YY, Quah EPL (2007) Antioxidant properties of Portulaca oleracea. Food Chem 103: 734-740 (IF: 2.43)

Lim YY, Lim TT, Tee JJ (2007) Antioxidant properties of several tropical fruits: A comparative study. Food Che:103: 1003-1008 (IF: 2.43)

Chan EWC, Lim YY, Omar M (2007) Antioxidant and antibacterial activity of leaves of Etlingera species (Zingiberaceae) in Peninsular Malaysia. Food Chem 104: 1586-1593 (IF: 2.43)

Lim YY, Murtijaya J (2007) Antioxidant properties of Phyllanthus amarus extracts as affected by different drying methods. LWT-Food Sci Technol 40: 1664-1669 (IF: 1.29)

2006 Publications

Lawrence C, Kadioglu A, Yang A-L, Coward W, Chow SC (2006) The Cathepsin B Inhibitor, z-FA-FMK is an immunosuppressive peptide that inhibits T cell proliferation and modulates host response to Pneumococcal infection. J Immunol 177:3827-3836 (IF: 6.0)

Coward WR, Marei A, Yang A, Vasa-Nicotera M, Chow SC (2006) Statin induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. J Immunol 176:5284-5298 (IF: 6.0)

Coward WR, Chow SC (2006) Effect of atorvastatin on TH1 and TH2 cytokine secreting cells during T cell activation and differentiation. Atherosclerosis 186:302-309. (IF: 4.60)

Chan EWC, Lim YY (2006) Antioxidant activity of Thunbergia laurifolia tea. J. Trop Forest Sci 18: 130-136 (IF: 0.113)

Ahmad, M, Langford, S J, Lim, YY, Vengidesh, P (2006) Optimisation of Reaction Condition for Preparing Carboxylmethyl Cellulose from Sago Waste” – Carbohydrate Polymers 64: 312-318. (IF: 1.58)

Zhang J, Goh JK, Tan WT, Bond AM (2006) Mechanistic analysis of the electrocatalytic properties of dissolved α and β isomers of [SiW 12O 40] 4 - and solid [Ru(bipy) 3] 2[α-SiW 12O 40] on the reduction of nitrite in acidic aqueous media. Inorganic Chemistry 45: 3732-3740. (IF: 3.45)

Gong, H, Hu, W-W, Pua, E (2006) Modulation of SAMDC expression in Arabidopsis thaliana alters in vitro shoot organogenesis, Physiologia Plantarum, Blackwell Munksgaard, Denmark, 128, 4: 740-750. (IF: 2.19)

2005 Publications

Iekhsan Othman, Muniandy, K.S., Naidu,R., Lee, M.W. and Dublin, N. (2005) Proteomics studies of prostate cancer among Malaysian men. Molecular and Cellular Proteomics, Vol4 (8), S123. (IF: 8.83)

YF Ngeow, S Suwanjutha, T Chantarojanasriri, F Wang, M Saniel, M Alejandria, PR Hsueh, PI Lee, SC Park, JW Sohn, A Aziah, Y Liu, WH Seto, CCL Ngan, M Hadiarto, A Hood and YM Cheong. (2005).. An Asian Study on the Prevalence of Atypical Respiratory Pathogens in Community-Acquired Pneumonia. International Journal of Infectious Diseases 9, 144-153. (IF: 2.21)

Muthiah YD, Lee WL, Teh LK, Ong CE and Ismail R (2005) Genetic polymorphism of CYP2C8 in three Malaysian ethnics: CYP2C8*2 and CYP2C8*3 are found in Malaysian Indians. Journal of Clinical Pharmacy and Therapeutics 30: 487-90. (IF: 1.75)

C. Simons, Q. Wu and T. T. Htar. Recent advances in antiviral nucleoside and nucleotide therapeutics. Current Topics in Medicinal Chemistry (2005), 5 (13), 1191. (IF: 4.27)

Uma D. Palanisamy and Christopher R. Lowe (2005). Characterisation of Glycoprotein Ligands Synthesised using Solid phase Combinatorial Chemistry, Journal of Chromatography A. 1075(1-2): 95-102 (IF: 3.76)