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Dr Ton So Ha

Senior Lecturer


PhD ( Aberdeen), FRCPath ( College of Pathologists, UK) Telephone: +603 - 5514 6102
Fax: +603 - 5514 6364
E-mail: ton.so.ha@artsci.monash.edu.my		 Links
Area of Expertise
Research Interest
Selected Journals
Current Research Projects
Prospective Research Projects
Research Students
Research Assistants
Abstracts  
Area of Expertise:

Human Biochemistry, Clinical Biochemistry/Chemical Pathology, Molecular Biology  
Research Interest:

Biochemistry and molecular biology of Hepatitis B and C infection, nutritional biochemistry in health and diseases, effect of compounds e.g. glycyrrhizic acid on lipid and carbohydrate metabolism .

Selected Journal Papers:


Ton SH, Iskandar K, Mazlam Z, Thanaletchimy N (2002) Core promoter/precore mutations in hepatitis B virus DNA from Malaysian carriers. Malaysian J Biochem Mol Biol 7:24-29.

Ton SH, Goh YS, Yee PC and Chan GL (2003) Copper and zinc levels in individuals undergoing haemodialysis. Ibid 8: 83

Ton SH, Tan TM, Khoo BS, Mazlam Z, Thanaletchimy N (2005) Hepatitis B Virus genotypes and Pre-core/core promoter mutations in Malaysian carriers. Ibid 12: 14-20

Ton SH, Shiela Kaur Gill, Low WY, Voon KQ (2005) Homocysteine, folic acid and vitamin C in young Malaysian smokers and non-smokers. Ibid12: 58-60

Lim CK, Tan TM, Khoo BS, Ravichandran A, Ton SH (2006) Correlation of HBV genotypes, mutations affecting HBeAg expression and HBeAg/antiHBe status in Malaysian HBV carriers. Int J Med Sci 3:14-20

Chia YY, Ton SH (2006) Urinary amino acid profiles in vegetarians and non-vegetarians: comparison of thin layer chromatography and high performance liquid chromatography. Malaysian J Biochem Mol Biol 13:56-60

Chai YY, Ton SH (2006) Full microscopic examination (FEME), pH and urinary specific gravity of vegetarians and non-vegetarians. Ibid13: 48-51

Chai YY, Ton SH (2006) Urinary amino acids profile of vegetarians and non-vegetarians. Malaysian J Nutri 12: 67-78

Lim CK, Low HM, Tan JTM, Khoo JBS, Ravichandran A, Ton SH (2007) Influences of HBV genotypes, core promoter mutations and HBe/Anti HBe titers on HBV-DNA levels. Malaysian J Biochem Mol Biol 15: 63-71

Lim CK, Tan JTM, Ravichandran A, Chan YC, Ton SH (2007) Comparison of PCR-based genotyping methods for hepatitis B virus. Malaysian J Pathol 29: 79-90

Lim CK, Ton SH (2007) Hepatitis B virus, genotypes and mutations affecting HBeAg productions: A Malaysian Perspective. J Med Health 2:1-25

Current Research Projects:

Effects of glycyrrhizic acid on lipid and glucose metabolism Effect of compounds e.g. glycyrhizic acid on glucose and lipid metabolism

Prospective Research Projects:

Effect of compounds e.g. glycyrhizic acid on glucose and lipid metabolism

Research Students:

PhD Student (Present)
  • Adeline Chai Yoke Yin : Effect of Gylcyrrhizic acid on glucose homeostasis and lipogenesis
Honours Students (Present)
  1. Tio Kai Ming : Cloning of PPAR gene and PPAR gamma 2 and determination of their levels in glycyrrhizic acid –treated rats
  2. Choh Leang Chung: 11β- hydroxysteroid dehydrogenases type 1 &2 and HOMA -IR in orally administered glycyrrhizic acid –treated rats for 1 week
  3. Liew Kah Leong : PPAR gamma 1 & 2 and HOMA –IR in orally- administered glycyrrhizic acid–treated rats for 1 week
  4. Alfred Lim : Lipoprotein lipase levels in orally-administered glycyrrhizic acid-treated- rats: correlation with lipid profile, total TAG and lipid deposition in adipose tissues
Honours Students (Past)
  1. Jason Khoo Boo Siang (2002): Detection of core promoter and precore mutations and their effects on HBeAg expresson in HBsAg-positive individuals
  2. Joanne Tan Tsui Ming (2003): Genotyping of Hepatitis B virus in Malaysian individuals using polymerase chain reaction:correlation with genotype-specific mutations and HBeAg/anti-HBe status
  3. Lim Chee Kent (2003): Hepatitis B genotyping using PCR-RFLP on the pre-S region and correlation with mutations affecting HBeAg production
  4. Aarthi Ravichandran (2003/4): Cloning and sequencing of the pre-S region of the hepatitis B virus DNA in HBsAg-positive individuals
  5. Chan Yin Chyi (2003):Cloning of large S gene of hepatitis B virus DNA from individuals infected with genotypes B, C and co-infected with genotypes B&C
  6. Low Hsin Mei (2004): Hepatitis B viral load quantitation and genotypes
  7. Adeline Chai Yoke Yin (2004): Urinary amino acids in vegetarians and non-vegetarians
  8. Ooi Li Lian (2005): Total PPAR gamma in glycyrrhizic acid-treated rats using western blotting
  9. Low Ley Hien (2006): PPAR gamma 1 & 2 in glycyrrhizic acid –treated rats using real time PCR
  10. Chua Eng Tat (2006): 11 β -hydroxysteroid dehydrogenase type 1 activities in glycyrrhizic acid- treated rats using HPLC and real –time PCR
  11. Tee Siang Lyn (2006): Detection of total PPAR gamma in rats treated with glycyrrhizic acid using immunochemical staining and Western blotting
  12. New Jia Yien (2007) : Detection of 11β-hydroxysteroid dehydrogenase type 1in rats given water- soluble glycyrrhizic acid
  13. Ho Chian (2007): Determination of PPAR gamma 1 &2 using Taq man probe ( real-time PCR)
  14. Goh Choo Peng (2007): Lipoprotein lipase, insulin and glucose in glycyrrhizic acid –treated rats
  15. Ng Shing Wei (Jan 2008): Lipoprotein lipase in rats on combination of normal and high fat diets and given glycyrrhizic acid
  16. Ivan Ng Eng Hian (Jan 2008): 11β—hydroxysteroid dehydrogenase levels in rats on combination of normal and high fat diet and given glycyrrhizic acid
 
Research Assistants:

Ms Goh Choo Peng is working on cloning of the lipoprotein lipase gene and determination of its level in glycyrrhizic acid- treated rats