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Dr Lau Yee Ling

Lecturer 

PhD ( University of Malaya, Malaysia)

Telephone: +603 - 5514 6113
Fax: +603 - 5514 6364
E-mail: lau.yee.ling@sci.monash.edu.my 		Links
Area of Expertise
Research Interest
Selected Journals
Current Research Projects
Prospective Research Projects
Research Assistants
Plenary / Keynote Lectures

Area of Expertise:

Molecular cloning and expression of antigens  

Research Interest:


Protozoan parasites of medical importance – Detection and molecular characterization  
Immunological characterization of parasites surface antigens

Selected Journal Papers:


Fong MY, Lau YL, Zulqarnain M (2007) Characterization of secreted recombinant Toxoplasma gondii surface antigen 2 (SAG2) heterologously expressed by the yeast Pichia pastoris. Biotechnol Lett [Epub ahead of print ISSN: 0141-5492 (Print) 1573-6776 (Online)]

Lau YL, Fong MY, Shamila Hisam, Mohamed Zulqarnain (2007) Recombinant expression of a truncated Toxoplasma gondii SAG2 surface antigen by the yeast Pichia pastoris. Southeast Asian J Trop Med Public Health 38:1-9

Lau YL, Shamila Hisam, Fong MY (2006) Characterization of a truncated Toxoplasma gondii surface antigen 2 (SAG2) secreted by the methylotrophic yeast Pichia pastoris. Trop Biomed 23:186-193

Yu HB, Zhang YL, Lau YL, Yao F, Vilches S, Merino S, Tomas JM, Howard SP, Leung KY (2005) Identification and characterization of putative virulence genes and gene clusters in Aeromonas hydrophila PPD134/91. Appl Environ Microbiol 71: 4469-4477

Fong MY, Lau YL (2004) Recombinant expression of the larval excretory-secretory antigen TES-120 of Toxocara canis in the methylotrophic yeast Pichia pastoris. Parasitol Res 92:173-176

Fong MY, Lau YL, Init I, Jamaiah I, Anuar AK, Rahmah N (2003) Recombinant expression of Toxocara canis excretory-secretory antigen TES-120 in Escherichia coli. Southeast Asian J Trop Med Public Health 34:723-726

Zhang YL, Lau YL, Arakawa E, Leung KY (2003) Detection and genetic analysis of group II capsules in Aeromonas hydrophila. Microbiology 149:1051-1060



Current Research Projects:


Centered on molecular cloning and expression of antigens using prokaryote and eukaryote systems. Some examples of potential projects are given below. Alternatively, students may wish to suggest a project of their own.
Prospective Research Projects:

  • Cloning and expression of surface antigen of Toxoplasma gondii using Pichia pastoris system
  • Optimization of culture conditions for expression
Research Assistants :


Lee Wei Wei
Recombinant expression of chimeric surface antigen SAG1/2 of Toxoplasma gondii by the yeast methylotrophic yeast, Pichia pastoris.

Marshita binti Mohd Idris
Recombinant expression of SAG1 and ROP3 of Toxoplasma gondii by the yeast methylotrophic yeast, Pichia pastoris.

Plenary / Keynote Lectures :

Lau YL, Fong MY (2007). Heterologous expression of the surface antigen SAG2 of Toxoplasma gondii in the methylotrophic yeast Pichia pastoris. 43 rd MSPTM annual scientific seminar and centenary celebration of the royal society of tropical medicine and hygiene ( UK), Kuala Lumpur, Malaysia.

Fong MY, Lau YL, Zulqarnain M (2006). Recombinant expression of a truncated Toxoplasma gondii surface antigen by the yeast Pichia pastoris. 5 th seminar on food and water borne parasitic zoonoses, Bangkok, Thailand.

Recombinant expression of the Toxoplasma gondii surface antigen SAG2 in the yeast Pichia pastoris (2006). 2 nd ASEAN congress of tropical medicine and parasitology, Indonesia.

Fong MY, Lau YL (2006). Yeast-derived recombinant antigens for use in immunodiganosis of parasite infections. 42 nd Annual scientific seminar of Malaysian society of parasitology and tropical medicine, Ipoh, Malaysia.